DRUG-INDUCED CHANGES IN BRAIN ACETYLCHOLINE

Drug-Induced Epigenetic Changes Produce Drug Tolerance

Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural adaptations. The slo gene encodes the pore-forming subunit of BK-type Ca(2+)-activated K(+) channels, which regulate many aspects of neural activity. Gi...

Drug-Induced Changes in Metabolomics of Plasma, Brain Extracellular Fluid and Cerebrospinal Fluid

Drug-induced QRS morphology and duration changes.

Drug-induced ECG changes may affect all components of the ECG curve. The attention of regulatory agencies, researchers and clinicians has been directed towards drug-induced QT-interval prolongation and its well-documented proarrhythmia. This presentation focuses on druginduced changes, i.e., morphology, amplitude and QRS complex duration (QRSd). A great variety of pharmacological agents (e.g., ...

Role of thymol in inhibition of acetylcholine induced contraction of isolated rat’s ileum

Introduction: Thymol has negative ionotropic effect on heart and has direct effect on calcium release from sarcoplasmic reticulum. Some of the herbal plants just like carum copticum consist of thymol. The postganglionic neurons of the gastrointestinal parasympathetic system are located mainly in the myenteric and submucosal plexuses. Stimulation of these parasympathetic nerves causes general...

Sex differences in drug-induced changes in ventricular repolarization.

INTRODUCTION Heart rate corrected QT (QTc) interval prolongation is a predictor of drug-induced torsade de pointes, a potentially fatal ventricular arrhythmia that disproportionately affects women. This study assesses whether there are sex differences in the ECG changes induced by four different hERG potassium channel blocking drugs. METHODS AND RESULTS Twenty-two healthy subjects (11 women) ...